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Drug interactions and pharmacokinetics news

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HIV treatment in children
Efavirenz may be under-dosed in children

In a cohort of three to 12 year-old HIV-infected Ugandan children taking once-daily efavirenz according to 2006 World Health Organization (WHO) weight-band dosing recommendations, lower and highly variable

Published
05 October 2011
By
Carole Leach-Lemens
HIV treatment in children
Crushing Kaletra tablets for kids leads to lower drug levels

Using crushed lopinavir/ritonavir (Kaletra) tablets in children with HIV because of difficulties in swallowing whole tablets should be avoided, American researchers report in the advance online edition of the

Published
23 September 2011
By
Carole Leach-Lemens
Drug interactions and pharmacokinetics
Older anti-epileptic drugs associated with failure of HIV treatment

An interaction means that some older anti-epileptic drugs and antiretroviral therapy should not be used together, a US study published in the open-access journal AIDS Research and Therapy

Published
02 September 2011
By
Michael Carter
Drug interactions and pharmacokinetics
Varying efficacy of HIV drug cocktails explained

A new mathematical model of HIV-fighting drugs reveals the biology beneath the varying success of such treatments. 

Published
13 July 2011
From
Science News
Neurological and cognitive problems
HIV disrupts blood-brain barrier: Cellular study suggests way virus may cause neurological deficits

HIV weakens the blood-brain barrier by overtaking a small group of supporting brain cells, according to a new study. The findings may help explain why some people living with HIV experience neurological complications, despite the benefits of modern drug regimens.

Published
28 June 2011
From
Science Daily
Drug interactions and pharmacokinetics
Certain Anti-Seizure Drugs Up the Risk of HIV Treatment Failure

People taking older anti-seizure medications that are broken down by the same liver enzyme (CYP3A4) as many common antiretroviral (ARV) drugs were more likely to experience treatment failure than people taking seizure medications that aren’t broken down by that liver enzyme.

Published
14 June 2011
From
AIDSMeds
Cancer
First Test of New Cancer Drug in People With HIV Is Promising

A newer cancer drug, Sutent (sunitinib), is tolerable when paired with at least some antiretroviral (ARV) drugs in people with HIV.

Published
06 June 2011
From
AIDSMeds.com
Tuberculosis and HIV
New findings on drug tolerance in TB suggest ideas for shorter cures

A study of host-pathogen responses in tuberculosis elucidates molecular mechanisms of antibiotic tolerance in tuberculosis and further suggests a strategy for shortening curative therapy (currently six months) using a class of drugs -- efflux pump inhibitors-- that are already approved for treating high blood pressure and angina, and available for use in people.

Published
03 March 2011
From
Eurekalert Inf Dis
New and experimental hepatitis C treatment
Telaprevir works well for people with HIV/HCV co-infection

The experimental hepatitis C virus (HCV) protease inhibitor telaprevir, used with pegylated interferon plus ribavirin, produced good virological response in the first study of HIV/HCV co-infected individuals, according to

Published
02 March 2011
By
Liz Highleyman
Drug interactions and pharmacokinetics
Study to analyze seizures in HIV patients, explore drug interactions

A Michigan State University researcher is looking to uncover the risks of treating seizures in HIV-positive patients, providing much-needed data on possible interactions between antiepileptic drugs and antiretroviral medicines that potentially could make HIV drugs less effective or the disease itself drug resistant.

Published
22 February 2011
From
Eurekalert Inf Dis
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